Basic Information
LncRNA/CircRNA Name | GAS5 |
Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
Region | GRCh38_1:173863900-173868882 |
Ensemble | ENSG00000234741 |
Refseq | NR_002578 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | breast cancer |
ICD-0-3 | C50 |
Methods | qPCR, RNAi, Western blot, ISH, MTT assay etc. |
Sample | cell lines (MCF-7 and MDA-MB-231) |
Expression Pattern | down-regulated |
Function Description | This negative correlation between miR-21 and GAS5 is also seen in breast tumor specimens. Of interest, GAS5 can also repress miR-21 expression. Whereas ectopic expression of GAS5 suppresses, GAS5-siRNA increases miR-21 expression. Experiments with in vitro cell culture and xenograft mouse model suggest that GAS5 functions as a tumor suppressor. |
Pubmed ID | 23933812 |
Year | 2013 |
Title | Negative regulation of lncRNA GAS5 by miR-21. |
External Links
Links for GAS5 | GenBank HGNC NONCODE |
Links for breast cancer | OMIM COSMIC |