Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, RNAi |
| Sample | cervical cancer tissues, Cervical cancer cell line (HeLa) |
| Expression Pattern | down-regulated |
| Function Description | GAS5 expression in cervical cancer tissues was significantly inhibited compared to that in adjacent tissues (p<0.05). GAS5 expression was correlated with FIGO stage and metastatic tumor parameters of cervical cancer patients (p<0.01). RNA interference data showed that the down-regulation of GAS5 significantly enhanced cell proliferation and invasion potency (p<0.05). |
| Pubmed ID | 29509242 |
| Year | 2018 |
| Title | Correlation between long strand non-coding RNA GASS expression and prognosis of cervical cancer patients. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |