Basic Information
| LncRNA/CircRNA Name | GAS5-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:173863248-173863941 |
| Ensemble | ENSG00000270084 |
| Refseq | NR_037605 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | NSCLC tissues, cell lines (A549, SPCA-1, H1299, H1703, H520, and PC-9) |
| Expression Pattern | down-regulated |
| Function Description | The expression of GAS5-AS1 in NSCLC tumors was much lower than that in the adjacent normal lung tissues. The reduced GAS5-AS1 was significantly correlated with larger tumors, higher TNM stages, and lymph node metastasis in NSCLC patients. Ectopic expression or downregulation of GAS5-AS1 influences NSCLC cell migration and invasion. |
| Pubmed ID | 27489122 |
| Year | 2016 |
| Title | Downregulation of the long noncoding RNA GAS5-AS1 contributes to tumor metastasis in non-small cell lung cancer. |
External Links
| Links for GAS5-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |