Basic Information
| LncRNA/CircRNA Name | GAS6-AS1 |
| Synonyms | NA |
| Region | GRCh38_13:113815630-113845744 |
| Ensemble | ENSG00000233695 |
| Refseq | NR_044995 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, Western blot |
| Sample | HCC tissues,cell lines (Hep3B, Huh7,and Bel-7402) |
| Expression Pattern | up-regulated |
| Function Description | GAS6-AS1 was significantly upregulated in HCC tissue samples and cell lines. Increased GAS6-AS1 expression was associated with tumor size, Edmondson grade, and Tumor-Node-Metastasis (TNM) stage among patients with HCC. |
| Pubmed ID | 32089066 |
| Year | 2020 |
| Title | Long non-coding RNA GAS6-AS1 acts as a ceRNA for microRNA-585, thereby increasing EIF5A2 expression and facilitating hepatocellular carcinoma oncogenicity |
External Links
| Links for GAS6-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |