Basic Information
| LncRNA/CircRNA Name | GAS8-AS1 |
| Synonyms | NA |
| Region | GRCh38_16:90028908-90029901 |
| Ensemble | ENSG00000221819 |
| Refseq | NR_122031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | PTC tissues and cell lines(BCPAP,TPC1) |
| Expression Pattern | down-regulated |
| Function Description | GAS8-AS1 was down-regulated in PTC cell lines and inhibited proliferation and cycle of PTC cell. GAS8-AS1 directly targets miR-135b-5p, and GAS8-AS1 could regulate a downstream target of miR-135b-5p, Cyclin G2 (CCNG2), in an miR-135b-5p-mediated manner. In addition, we also proved that overexpressed GAS8-AS1 inhibited tumor formation in vivo GAS8-AS1 suppresses PTC cell growth through the miR-135b-5p/CCND2 axis. |
| Pubmed ID | 30429236 |
| Year | 2019 |
| Title | LncRNA GAS8-AS1 Suppresses Papillary Thyroid Carcinoma Cell Growth Through the miR-135b-5p/CCND2 Axis |
External Links
| Links for GAS8-AS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |