Basic Information
| LncRNA/CircRNA Name | GASL1 |
| Synonyms | NA |
| Region | GRCh38_8:102805517-102809971 |
| Ensemble | ENSG00000253669 |
| Refseq | NR_149020 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (U2OS and SAOS-2) |
| Expression Pattern | up-regulated |
| Function Description | The real-time PCR analysis demonstrated that activation of the ectopic E2F1 increased expression of GASL1 in both U2OS and H1299 cell lines. These results demonstrate that GASL1 plays a crucial role in osteosarcoma cell growth in vivo. |
| Pubmed ID | 28423601 |
| Year | 2017 |
| Title | A novel lncRNA, GASL1, inhibits cell proliferation and restricts E2F1 activity |
External Links
| Links for GASL1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |