Basic Information
| LncRNA/CircRNA Name | GATA2-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:128489212-128502348 |
| Ensemble | ENSG00000244300 |
| Refseq | NR_125398 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot , RNAi , RIP etc. |
| Sample | lung cancer tissues and adjacent noncancerous tissues ,cell lines(HEK 293T cells ,A549 cells) |
| Expression Pattern | down-regulated |
| Function Description | GATA2-AS1, repressing NSCLC cells proliferation via regulating GATA2.Most of cancer tissues expressed lower levels of GATA2-AS1 compared with adjacent noncancerous tissues.GATA2-AS1 gene is located at antisense strand of GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein at promoter region of GATA2 and then inhibits its transcription. Moreover, GATA2-AS1 is transcriptionally repressed by MYC in NSCLC cells. |
| Pubmed ID | 31607132 |
| Year | 2019 |
| Title | A MYC Target Long Non-Coding RNA GATA2-AS1 Regulates Non-Small Cell Lung Cancer Growth |
External Links
| Links for GATA2-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |