Basic Information
| LncRNA/CircRNA Name | GATA6-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR etc. |
| Sample | gastric cancer and adjacent normal tissues ,blood samples , gastric cancer cell lines (SNU-1 and AGS) |
| Expression Pattern | down-regulated |
| Function Description | GATA6-AS was downregulated in tumor tissues compared with adjacent normal tissues. Moreover, plasma levels of GATA6-AS were linearly associated with GATA6-AS expression levels in tumor tissues and not in normal tissues.miR-25-3p was upregulated in tumor tissues compared with adjacent normal tissues and was inversely associated with GATA6-AS in tumor tissues only.Overexpression of GATA6-AS led to significantly downregulated miR-25-3p levels.Overexpression of GATA6-AS inhibited cancer cell proliferation, with no effect on migration and invasion. The overexpression of miR-25-3p resulted in increased proliferation of cancer cells and attenuated the effects of GATA6-AS overexpression. |
| Pubmed ID | 31611972 |
| Year | 2019 |
| Title | Long Non-Coding RNA GATA6-AS Inhibits Gastric Cancer Cell Proliferation by Downregulating microRNA-25-3p |
External Links
| Links for GATA6-AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |