Basic Information
| LncRNA/CircRNA Name | GATA6-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical squamous cell carcinoma |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, other |
| Sample | CSCC tissues and cell lines, serum |
| Expression Pattern | up-regulated |
| Function Description | In addition, serum levels of GATA6-AS were higher in patients compared with healthy controls. The serum levels of GATA6-AS were associated with tumor metastasis, and may serve as a potential diagnostic and prognostic marker for cervical squamous cell carcinoma. Furthermore, GATA6-AS overexpression inhibited cancer cell migration and invasion. The expression levels of MTK-1 were also reduced following GATA6-AS overexpression. Therefore, the present study proposed that downregulated GATA6-AS expression was associated with tumor metastasis in cervical squamous cell carcinoma, and that GATA6-AS expression may inhibit cancer cell migration and invasion by downregulating MTK-1. |
| Pubmed ID | 31404324 |
| Year | 2019 |
| Title | Upregulation of lncRNA GATA6-AS Suppresses the Migration and Invasion of Cervical Squamous Cell Carcinoma by Downregulating MTK-1 |
External Links
| Links for GATA6-AS | GenBank HGNC NONCODE |
| Links for cervical squamous cell carcinoma | OMIM COSMIC |