Basic Information
| LncRNA/CircRNA Name | GATA6-AS1 |
| Synonyms | NA |
| Region | GRCh38_18:22166898-22168968 |
| Ensemble | ENSG00000266010 |
| Refseq | NR_102763 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot |
| Sample | GC tissues,cell lines (SGC7901, MKN45, BGC-27, HGC-27, and AGC) |
| Expression Pattern | down-regulated |
| Function Description | GATA6-AS1 was poorly expressed, but FZD4 was highly expressed in GC tissues and cells.overexpressed GATA6-AS1 down-regulated the expression of FZD4 to inactivate the Wnt/b-catenin signaling pathway, which ultimately inhibited GC progression. |
| Pubmed ID | 31981860 |
| Year | 2019 |
| Title | Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/b-Catenin Signaling Pathway in GC |
External Links
| Links for GATA6-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |