Basic Information
| LncRNA/CircRNA Name | GHET1 |
| Synonyms | NA |
| Region | GRCh38_7:148987527-148989432 |
| Ensemble | ENSG00000281189 |
| Refseq | NR_130107 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc |
| Sample | cervical cancer tissues,cell lines (HeLa and SiHa) |
| Expression Pattern | down-regulated |
| Function Description | The GHET1 knockdown (si-GHET1) groups showed significantly higher G1 phase and apoptosis rates and significantly suppressed invasion and migration abilities compared with the normal control (NC) group (P< 0.05 for all). The expression levels of PTEN, PI3 K, AKT, P53, matrix metalloproteinase (MMP)-2 and MMP-9 proteins differed significantly between the si-GHET1 and NC groups (P< 0.05 for all). |
| Pubmed ID | 32176622 |
| Year | 2020 |
| Title | Knockdown of Long Non-Coding RNA GHET1 Suppresses Cervical Carcinoma in Vitro and in Vivo |
External Links
| Links for GHET1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |