Basic Information
| LncRNA/CircRNA Name | GHET1 |
| Synonyms | NA |
| Region | GRCh38_7:148987527-148989432 |
| Ensemble | ENSG00000281189 |
| Refseq | NR_130107 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | PC tissues, The human prostate adenocarcinoma cell lines, LNCap and C4-2 cell lines |
| Expression Pattern | up-regulated |
| Function Description | GHET1 showed higher expression in PC tissues and had a negative correlation with KLF2 expression. Knockdown of GHET1 significantly suppressed the cell proliferation, induced cell cycle arrest at G0/G1 phase and promoted cell apoptosis. Additionally, si-GHET1 transfection induced KLF2 upregulation and HIF-1?/Notch-1 signal pathway suppression, which could be rescued by si-KLF2 transfection. These results suggest the key role of GHET1 in PC progression. |
| Pubmed ID | 30609158 |
| Year | 2019 |
| Title | Knockdown of LncRNA GHET1 suppresses prostate cancer cell proliferation by inhibiting HIF-1?/Notch-1 signaling pathway via KLF2. |
External Links
| Links for GHET1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |