Basic Information
| LncRNA/CircRNA Name | GHET1 |
| Synonyms | GHET1, lncRNA-GHET1 |
| Region | GRCh38_7:148987527-148989432 |
| Ensemble | ENSG00000281189 |
| Refseq | NR_130107 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR etc. |
| Sample | cell lines (SWl990, CFPAC-1, Panc-1, BxPC-3, L3.6P1) |
| Expression Pattern | up-regulated |
| Function Description | The expression of GHET1 in human pancreatic cancer cells was relatively high. The results of CCK-8 showed that the proliferation of tumor cells was inhibited after the interference with GHET1 expression. The results of flow cytometry showed that the expression of GHET1 was blocked at G1/G0 phase, and the apoptosis rate was increased. The results of qRT-PCR showed that the expression of GHET1 was upregulated in pancreatic cancer tissues of 49 out of 64 patients compared with that in cancer-adjacent tissues, and the highly expressed GHET1 was positively correlated with the tumor, node and metastasis (TNM) staging of pancreatic cancer. |
| Pubmed ID | 29228419 |
| Year | 2017 |
| Title | Expression and clinical significance of long-non-coding RNA GHET1 in pancreatic cancer |
External Links
| Links for GHET1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |