Basic Information
| LncRNA/CircRNA Name | GIAT4RA |
| Synonyms | LOC102723729 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP, RNAi, other |
| Sample | lung cancer tissues and cell lines (A549, H358, H522) |
| Expression Pattern | down-regulated |
| Function Description | Higher expression of GIAT4RA was linked with overall survival in NSCLC. GIAT4RA inhibited many characteristics of tumorigenesis including cell growth, clonal formation, migration and invasion, epithelial-mesenchymal transition, tumor sphere and tumor growth in vivo. Mechanistically, GIAT4RA was essential for the degradation of chromatin modifier lymphoid-specific helicase (LSH) by counteracting the deubiquintination in proteasome pathway by binding to 227-589 AA of LSH. GIAT4RA interfered with ubiquitin hydrolase Uchl3-mediated interaction and stabilization of LSH. LSH knockdown rescued GIAT4RA-promoted features, and LSH overexpression prevented GIAT4RA-induced phenotypes. |
| Pubmed ID | 31417184 |
| Year | 2019 |
| Title | GIAT4RA Functions as a Tumor Suppressor in Non-Small Cell Lung Cancer by Counteracting Uchl3-mediated Deubiquitination of LSH |
External Links
| Links for GIAT4RA | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |