Basic Information
| LncRNA/CircRNA Name | GUARDIN |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | Microarray, Luciferase reporter assay, in vitro knockdown, RNAi etc. |
| Sample | cell line (HCT116, U2OS, A549, H1299, 293T and HAFF), colon cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | GUARDIN is necessary for preventing chromosome end-to-end fusion through maintaining the expression of telomeric repeat-binding factor 2 (TRF2) by sequestering microRNA-23a.Moreover, GUARDIN also sustains breast cancer 1 (BRCA1) stability by acting as an RNA scaffold to facilitate the heterodimerization of BRCA1 and BRCA1-associated RING domain protein 1 (BARD1).As such, GUARDIN silencing triggered apoptosis and senescence,enhanced cytotoxicity of additional genotoxic stress and inhibited cancer xenograft growth. Thus, GUARDIN may constitute a target for cancer treatment. GUARDIN functions to regulate TRF2 and IRF1 through sequestering miR-23a. |
| Pubmed ID | 29593331 |
| Year | 2018 |
| Title | GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability. |
External Links
| Links for GUARDIN | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |