Basic Information
| LncRNA/CircRNA Name | AK001796 |
| Synonyms | MIR4435-2HG, AGD2, AK001796, LINC00978, MIR4435-1HG, MIR4435-2HG |
| Region | GRCh38_2:111036776-111523376 |
| Ensemble | ENSG00000172965 |
| Refseq | NR_015395 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown etc |
| Sample | cell lines (Eca-109,TE-1), ESCC tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA AK001796 was significantly upregulated in ESCC tumor tissues.lncRNA AK001796 regulates cell proliferation and cell cycle via modulating MDM2/p53 signaling in ESCC, which provides a new insight into the treatment targets for ESCC. |
| Pubmed ID | 29568233 |
| Year | 2018 |
| Title | The long non-coding RNA AK001796 contributes to tumor growth via regulating expression of p53 in esophageal squamous cell carcinoma. |
External Links
| Links for AK001796 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |