Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Western blot |
| Sample | BC tissues,cell lines (MDA-231, MCF-7,SK-BR-3 and T-47D) |
| Expression Pattern | up-regulated |
| Function Description | the H19/let-7/Lin28 loop was revealed to promote EMT in BC cells. Moreover, the H19/let-7/Lin28 network was found to contribute to autophagy by inhibiting EMT in BC cells. |
| Pubmed ID | 32124962 |
| Year | 2019 |
| Title | H19/let-7/Lin28 ceRNA network mediates autophagy inhibiting epithelial-mesenchymal transition in breast cancer |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |