Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-qPCR, Western blot |
| Sample | ovarian cancer OVCAR3 cell line |
| Expression Pattern | up-regulated |
| Function Description | The level of lncRNA H19 in the OVCAR3/DDP cells was significantly elevated compared with the OVCAR3 cells.The overexpression of lncRNA in the OVCAR3 cells improved the cisplatin-resistance, and the inhibition of lncRNA H19 expression in OVCAR3/DDP cells eliminated the cisplatin resistance. |
| Pubmed ID | 31934077 |
| Year | 2019 |
| Title | Long Non-Coding RNA H19 Mediates Ovarian Cancer Cell Cisplatin-Resistance and Migration During EMT |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |