Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-PCR , Western blot etc. |
| Sample | A549 cells |
| Expression Pattern | up-regulated |
| Function Description | The three LncRNA H19 shRNAs used in our study significantly reduced the expression levels of LncRNA H19 in A549 cells.Transfection with shLncRNA H19-2 significantly decreased the proliferation, migration, and invasion of A549 cells, while overexpression of LncRNA H19 had the opposite effect in these cells. In response to shLncRNA H19-2, the expression levels of E-cadherin were notably elevated, while the expression levels of N-cadherin and vimentin were decreased. In contrast, overexpression of LncRNA H19 induced the expression of E-cadherin, and blocked the expression of N-cadherin, and vimentin . |
| Pubmed ID | 31190899 |
| Year | 2019 |
| Title | Long Non-Coding RNA H19 Promotes the Proliferation and Invasion of Lung Cancer Cells and Regulates the Expression of E-cadherin, N-cadherin, and Vimentin |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |