Basic Information
| LncRNA/CircRNA Name | AK021443 |
| Synonyms | HELLS, ICF4, LSH, Nbla10143, PASG, SMARCA6 |
| Region | GRCh38_10:94501434-94613905 |
| Ensemble | ENSG00000119969 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR |
| Sample | hepatocellular carcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | The results revealed that AK021443 expression levels were significantly higher in HCC tissues than in the corresponding noncancerous tissues. high AK021443 expression was correlated with poor tumor differentiation (p = 0.002), advanced clinical stage (p=0.001) and positive lymph node metastasis (p=0.005). In addition, the Kaplan-Meier survival curves revealed that HCC patients with high AK021443 expression level had shorter overall survival than those with low AK021443 expression level (p=0.0005). |
| Pubmed ID | 30070318 |
| Year | 2018 |
| Title | Increased Expression of Long Noncoding RNA AK021443 Predicts Worse Clinical Outcome in Hepatocellular Carcinoma. |
External Links
| Links for AK021443 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |