Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | GC tissues and para-cancerous tissues ,AGS and normal gastric mucous epithelium cells (GES-1), BGC-823, MKN-45 and SGC-7901 |
| Expression Pattern | up-regulated |
| Function Description | H19 was found to be upregulated in GC tissues and cells compared with the para-cancerous tissues, and an elevated expression of H19 was associated with lymph node metastasis and TNM stage.Furthermore, the downregulation of H19 suppressed the proliferation, invasion, migration and epithelial-mesenchymal transition of GC cells in vitro and suppressed tumor growth in vivo.H19 promoted tumor growth and metastasis via the miR-22-3p/Snail1 signaling pathway. |
| Pubmed ID | 31081061 |
| Year | 2019 |
| Title | Long Non-coding RNA H19 Regulates Cell Growth and Metastasis via the miR-22-3p/Snail1 Axis in Gastric Cancer |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |