Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR etc. |
| Sample | tumor and tumor-adjacent healthy tissues ,blood was extracted from each participant ,breast cancer cell lines(BT-549 and HCC71) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA H19 was upregulated and was inversely correlated with PTCSC3 in tumor tissues.PTCSC3 overexpression led to downregulated H19 in TNBC cells, while H19 overexpression did not affect PTCSC3 expression.PTCSC3 inhibited and H19 promoted proliferation of TNBC cells.H19 overexpression attenuated the effects of PTCSC3 overexpression.PTCSC3 inhibits TNBC cell proliferation by downregulating lncRNA H19. |
| Pubmed ID | 31026090 |
| Year | 2019 |
| Title | LncRNA PTCSC3 Inhibits Triple-Negative Breast Cancer Cell Proliferation by Downregulating lncRNA H20 |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |