Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR , Western blot , in vitro knockdown etc. |
| Sample | colon tissues ,colon cancer cells(Caco-2 ,HT-29), liver cancer cells C3A ,prostate cancer cells PC3 ,human skin fibroblasts |
| Expression Pattern | down-regulated |
| Function Description | H19 was down-regulated following FECH silencing in Caco-2 cells, when compared to controls.However, no effect on H19 expression was observed in normal fibroblasts after FECH knockdown .Altogether, H19 might be one of FECH targets in colon cancer cells. Thus, a better prognosis of colon cancer could be directly linked to the loss of FECH and subsequently decreased levels of H19.FECH is a potential regulator of H19 and targeting it may offer a potential treatment for colon cancer as well as other cancers. This regulation might be through the RAS signaling pathway as both seem to be players in this process. |
| Pubmed ID | 31602323 |
| Year | 2019 |
| Title | Loss of Ferrochelatase Is Protective Against Colon Cancer Cells: Ferrochelatase a Possible Regulator of the Long Noncoding RNA H19 |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |