Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR |
| Sample | CRC tissue, the adjacent colorectal mucosa tissues |
| Expression Pattern | up-regulated |
| Function Description | H19 and MALAT1 expression were higher in CRC tissues than in normal colorectal mucosa (p ? 1.59 106 and p ? 6.95 109 , respectively), whereas lincRNA-p21 showed lower expression in CRC tissues (p ? 1.10 104 ). Logistic regression analysis results indicated that the expression of H19 was significantly lower in CRC patients with T2DM compared with CRC patients without T2DM (p ? .032). H19 expression in CRC group without T2DM was significantly associated with hypertension (p ? .040). Additionally, the area under the receiver operating characteristic curve of H19 was 0.672 of the group CRC with T2DM, which suggests that H19 could be a useful biomarker and predictive targets for diagnosis of T2DM in CRC patients. |
| Pubmed ID | 31232113 |
| Year | 2019 |
| Title | Expression of long non-coding RNA H19 in colorectal cancer patients with type 2 diabetes |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |