Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR |
| Sample | The CACX cell lines (SiHa, C33A and HeLa,), Tissue samples of primary cervical lesions and 5ml of blood as well as Normal cervical epithelial (NCE) tissue |
| Expression Pattern | down-regulated |
| Function Description | 8 over-expressed transcribed pseudogenes (GBP1P1, HLADRB6, HLA-H, SLC6A10P, NAPSB, KRT16P2, PTTG3P and RNF126P1), down-regulated 7 lincRNAs (H19, MIR100HG, MEG3, DIO3OS, HOXA11-AS, CD27-AS1 and EPB41L4A-AS) and 6 snoRNAs (SNORD97, SNORD3A, SNORD3C, SNORD3D, SNORA12 and SCARNA9) as DEncGs (log2 fold-change ???1.0) in CACX. Consequently, down-regulation of lincRNA MEG3 and over-expression of pseudogenes, GBP1P1 and PTTG3P in the microarray analysis were found concordant with the real-time quantitative PCR results upon validation. Then, Ingenuity? Pathway analysis (IPA? ) analysis with deregulated DEncGs identified functionally important gene, H19. Further, validation (n=52) of expression confirmed frequent downregulation of H19 with significant association with its deletion (LOH) and promoter methylation (n=128) in CACX. Moreover, clinico-pathological analysis found Indian CACX patients (n=26) with alterations of H19 by deletion or, promoter methylation with concomitant low expression have poor prognosis. |
| Pubmed ID | 31229557 |
| Year | 2019 |
| Title | Deregulation of H19 is associated with cervical carcinoma |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |