Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR etc. |
| Sample | blood |
| Expression Pattern | differential expression |
| Function Description | A significantly decreased risk of bladder cancer was found for the rs2839698 TC genotype, but not for CC homozygotes. The rs2839698 TC genotype was especially associated with a reduced risk of developing non-muscle-invasive disease. Borderline significantly decreased risks of bladder cancer were found for the rs2107425 CT genotype, but not for TT homozygotes or for T allele carriers of rs217727. Haplotype analysis did not result in stronger associations with bladder cancer compared with the single-locus analyses. An SNP polymorphism in the non??rotein-encoding H19 gene is associated with a decreased risk of developing non??uscleinvasive bladder cancer. This association was found for only heterozygotes, not for homozygotes. |
| Pubmed ID | 18262338 |
| Year | 2008 |
| Title | Polymorphisms in the H19 gene and the risk of bladder cancer. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |