Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | malignant melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell line (A375, SK-MEL-1, SK-MEL-5), melanoma tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA H19 was increased in melanoma tissue,and lncRNA H19 was correlated with poor prognosis of melanoma patients.miR-106a-5p acts as a tumour suppressor in melanoma by targeting E2F3.E2F3 affects the melanoma cell glucose metabolism and growth.lncRNA H19 may function as the sponge of miR-106a-5p to up-regulate E2F3 expression,and consequently promote the glucose metabolism and growth of melanoma. |
| Pubmed ID | 29350287 |
| Year | 2018 |
| Title | Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p/E2F3 axis. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for malignant melanoma | OMIM COSMIC |