Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue squamous cell carcinoma |
| ICD-0-3 | C02 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | cell line (CAL27, SCC9, SCC15, SCC25, FaDu), TSCC tissues |
| Expression Pattern | up-regulated |
| Function Description | Depletion of H19 impaired the migration and invasion ability of TSCC cells.Mechanisticlly,H19 functions as a competing endogenous RNA (ceRNA) to sponge miRNA let-7a,leading to an increase in a let-7a target, the key regulator of tumor metastasis HMGA2,which is enriched in TSCC tissues and cell lines.Intriguingly,inhibition of let-7a significantly rescued short hairpin H19 (shH19) induced decrease of TSCC migration and invasion.H19/let-7a/HMGA2/EMT axis plays a critical role in the regulation of TSCC migration and invasion,which may provide a new therapeutic target for TSCC cancers. |
| Pubmed ID | 29523225 |
| Year | 2018 |
| Title | H19 facilitates tongue squamous cell carcinoma migration and invasion via sponging miR-let-7. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for tongue squamous cell carcinoma | OMIM COSMIC |