Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | melanoma tissues, cell lines (C32, SK-MEL-28 and CCD-1059Sk) |
| Expression Pattern | up-regulated |
| Function Description | The results revealed that the expression level of H19 was significantly higher in tumor tissue than in the adjacent healthy tissue of 47 out of 49 patients. H19 knockdown significantly reduced the proliferation, migration and invasion ability of melanoma cells. H19 knockdown also inactivated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, which in turn inhibited the activation of the NF-kB signaling pathway. Thus, downregulation of lncRNA H19 may inhibit the migration and invasion of melanoma cells by inactivating the NF-kB signaling pathway via the inactivation of the PI3K/Akt signaling pathway. |
| Pubmed ID | 29568965 |
| Year | 2018 |
| Title | Downregulation of lncRNA H19 inhibits the migration and invasion of melanoma cells by inactivating the NF-kB and PI3K/Akt signaling pathways. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |