Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes.Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma. |
| Pubmed ID | 26272696 |
| Year | 2015 |
| Title | CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |