Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | choriocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Northern blot etc. |
| Sample | cell lines (Bewo, CC1, CC2, CC3, NUC1, JEG3, HM, JAR, GCH1, and NJG) |
| Expression Pattern | up-regulated |
| Function Description | Choriocarcinomas were characterized by a low expression of IGF2 and a high expression of H19 with the transcripts being apparently intact in size. Biallelic expression of IGF2 or H19 was found frequently but not consistently in choriocarcinomas. Contrary to expectation, enhanced H19 expression was accompanied by hypermethylation of CpG sites over the entire gene region, apparently being at variance with the finding in normal placentae and androgenetic moles. |
| Pubmed ID | 9062579 |
| Year | 1997 |
| Title | Association of IGF2 and H19 imprinting with choriocarcinoma development. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for choriocarcinoma | OMIM COSMIC |