Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | pancreatic ductal adenocarcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | the suppressed cell proliferation caused by H19 knockdown could be rescued by inhibiting miR-675 expression.As a transcript of the first exon of H19,the level of miR-675 was negatively correlated with H19 expression in microdissected PDAC tissues.And the decrease of E2F-1 protein expression caused by siH19 could be partially reversed by miR-675 knockdown.there might be a H19/miR-675/E2F-1 regulatory loop in cell cycle modulation. |
| Pubmed ID | 29344285 |
| Year | 2018 |
| Title | Long noncoding RNA H19 derived miR-675 regulates cell proliferation by down-regulating E2F-1 in human pancreatic ductal adenocarcinoma. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |