Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (A549, H1299 and BES-2B) |
| Expression Pattern | up-regulated |
| Function Description | H19 was upregulated in A549 and H1299 cells compared to normal lung epithelial BEAS-2B cells. Meanwhile,miR-17 was downregulated in NSCLC cell lines. Overexpression of miR-17 was able to inhibit the progression of NSCLC cells while reversely miR-17 inhibitors reversed this process.In addition, signal transducers and activators of transcription (STAT3),as an mRNA target of miR-17,was presented in our research.Moreover, we discovered that H19 demonstrated its biological functions via regulating miR-17 and STAT3 in vitro.Silencing H19 greatly increased STAT3 expression by sponging miR-19 in vitro.It was hypothesized that H19 may serve as a competing endogenous RNA (ceRNA) to modulate STAT3 by attaching miR-17 in lung cancer. |
| Pubmed ID | 29693721 |
| Year | 2018 |
| Title | H19 promotes non-small-cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR-17. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |