Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, western blot, luciferase reporter assay |
| Sample | colon cancer tissues, cell lines (SW480, HT-29, colon26, HCT-8, and RKO) |
| Expression Pattern | differential expression |
| Function Description | H19 shRNA strongly reduced the tumor growth and tumor volume. H19 shRNA also inhibited metastasis via suppressing hepatic metastases and the expression of metastasis-related proteins. Taken together, our research indicated an H19-miR138-HMGA1 pathway in regulating the migration and invasion of colon cancer, |
| Pubmed ID | 28358427 |
| Year | 2017 |
| Title | H19 promotes the migration and invasion of colon cancer by sponging miR-138 to upregulate the expression of HMGA1 |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |