Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | glioma tissues, cell lines (U87, U251 etc.) |
| Expression Pattern | up-regulated |
| Function Description | By analyzing glioma gene expression data sets, we found increased H19 in high grade gliomas. H19 depletion via siRNA inhibited invasion in glioma cells. Further, we found H19 positively correlated with its derivate miR-675 expression and reduction of H19 inhibited miR-675 expression. |
| Pubmed ID | 24466011 |
| Year | 2014 |
| Title | Long non-coding RNA H19 promotes glioma cell invasion by deriving miR-675. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |