Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | BC patients tissues |
| Expression Pattern | up-regulated |
| Function Description | In our study, we confirmed that the T variant of rs217727 was consistently associated with an increased risk of BC in the codominant model.Another previous study by Yang et al32 found that the rs217727 CT + TT genotypes were correlated with significantly increased gastric cancer risk (OR 1.32, 95% CI 1.01-1.71), while in functional assay analysis, the rs217727 CT, TT, or CT + TT genotypes were found not to affect H19 mRNA expression levels compared with the CC genotype, suggesting the C/T mutation might potentially change translational efficiency and lead to a transformation in H19 structure, thereby influencing the function of H19. |
| Pubmed ID | 28919786 |
| Year | 2017 |
| Title | Genetic variants in long noncoding RNA H19 contribute to the risk of breast cancer in a southeast China Han population. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |