Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot etc. |
| Sample | hepatocellular carcinoma tissues, cell line Huh 7 |
| Expression Pattern | down-regulated |
| Function Description | The study provides evidence that downregulation of H19 may induce OS and reverse chemotherapy resistance of CD133 cancer stem cells by blocking the MAPK/ERK signaling pathway in HCC. |
| Pubmed ID | 29800569 |
| Year | 2018 |
| Title | Effect of long non-coding RNA H19 on oxidative stress and chemotherapy resistance of CD133+ cancer stem cells via the MAPK/ERK signaling pathway in hepatocellular carcinoma |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |