Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | CML tissue |
| Expression Pattern | down-regulated |
| Function Description | Results showed that HAND2-AS1 was significantly downregulated than healthy control (p<0.05), and HAND2 -AS1 expressions on stages of AP and BP were much lower than that of CP (p<0.05). The miR-1275 expression was significantly upregulated than healthy control (p<0.05), and the expressions in stages of accelerated phase (AP) and blast phase (BP) were much higher than that in the stage of chronic phase (CP) in CML (p<0.05). |
| Pubmed ID | 30915755 |
| Year | 2019 |
| Title | LncRNA HAND2-AS1 inhibits proliferation and promotes apoptosis of chronic myeloid leukemia cells by sponging with micRNA-1275. |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for chronic myeloid leukemia | OMIM COSMIC |