Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | HAND2 antisense RNA 1 |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | Microarray, Dual luciferase reporter assay, RIP, RT-qPCR, Western blot analysis |
| Sample | Tumor tissues,human cervical adenocarcinoma (HeLa) (3111C0001CCC000011) and Ca Ski (3111C0001CCC000101) cells,C-33A (3111C0001CCC000172) cells,H1HeLa cells (3111C0001CCC000344) |
| Expression Pattern | down-regulated |
| Function Description | Low expression of HAND2-AS1 and LDOC1, and high expression of miR-330-5p were detected in cervical cancer tissues and cells.Also, overexpressed HAND2-AS1 and LDOC1 or down-regulated miR-330-5p inhibited expression of proliferation-associated proteins Ki-67, PCNA, migration-associated proteins N-cad and invasion-related proteins MMP-2, MMP-9 as well as lymph node metastasis. Moreover, HAND2-AS1 inhibited tumor formation and lymph node metastasis by binding to miR-330-5p in vivo. |
| Pubmed ID | 31889905 |
| Year | 2019 |
| Title | HAND2-AS1 Inhibits Invasion and Metastasis of Cervical Cancer Cells via microRNA-330-5p-mediated LDOC1 |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |