Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Western blot analysis, Dual luciferase reporter assay |
| Sample | BC tissues,breast epithelial cell line MCF10A and 84 breast cancer cells MDA-MB-231, MDA-MB-468, 85 MCF-7 and UACC812 |
| Expression Pattern | down-regulated |
| Function Description | Downregulation of HAND2-AS1 was detected in breast cancer and was associated with adverse clinical features and prognosis. Furthermore, overexpression of HAND2-AS1 restrained cell viability, migration and invasion in breast cancer. In addition, reciprocal suppression between HAND2-AS1 and miR-1275 was identified in breast cancer cells. |
| Pubmed ID | 31683462 |
| Year | 2020 |
| Title | Long Noncoding RNA HAND2-AS1 Restrains Proliferation and Metastasis of Breast Cancer Cells Through Sponging miR-1275 and Promoting SOX7 |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |