Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase assay |
| Sample | cell lines (HT29, SW480, SW620, LoVo, HCT116) |
| Expression Pattern | down-regulated |
| Function Description | we found that lncRNA HAND2-AS1 was markedly downregulated in CRC tissues. And its expression level was negatively correlated with metastasis and advanced stage in CRC patients. we showed that HAND2-AS1 low expression predicted poor prognosis. we found that overexpression of HAND2-AS1 obviously attenuated the proliferation and invasion of CRC cells. HAND2-AS1 served as a sponge of miR-1275 which targeted KLF14. |
| Pubmed ID | 30078677 |
| Year | 2018 |
| Title | LncRNA HAND2-AS1 Sponging miR-1275 Suppresses Colorectal Cancer Progression by Upregulating KLF14. |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |