Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | HAND2-AS1, DEIN, NBLA00301, UPH |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, other |
| Sample | osteosarcoma tissues and cell lines (MG-63, SAOS-2), blood |
| Expression Pattern | down-regulated |
| Function Description | The results revealed that the expression levels of HAND2-AS1 were reduced in cancer tissues compared with those in healthy tissues. Levels of HAND2-AS1 were also reduced in the serum of patients with osteosarcoma compared with those of the control subjects. A significant association was observed between serum levels of HAND2-AS1 and tumor size, but not tumor metastasis. HAND2-AS1-knockdown promoted osteosarcoma cell proliferation, increased glucose uptake and upregulated GLUT1 expression. |
| Pubmed ID | 31423193 |
| Year | 2019 |
| Title | Long Non-Coding RNA HAND2-AS1 Targets Glucose Metabolism and Inhibits Cancer Cell Proliferation in Osteosarcoma |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |