Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | HAND2-AS1, DEIN, NBLA00301, UPH |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, other |
| Sample | melanoma tissues and cell lines (C32, SK-MEL-28) |
| Expression Pattern | down-regulated |
| Function Description | Expression levels of lncRNA HAND2-AS1 and ROCK1 were inversely correlated in tumor tissues, but not in healthy tissues. LncRNA HAND2-AS1 expression levels were affected by tumor thickness, but not by tumor metastasis. LncRNA HAND2-AS1 overexpression led to inhibited melanoma cancer cell proliferation and an increased expression level of ROCK1. ROCK1 overexpression caused no evident effects on lncRNA HAND2-AS1 expression, but promoted cancer cell proliferation and decreased the effects of lncRNA HAND2-AS1 overexpression on cancer cell proliferation. |
| Pubmed ID | 31423160 |
| Year | 2019 |
| Title | LncRNA HAND2-AS1 Overexpression Inhibits Cancer Cell Proliferation in Melanoma by Downregulating ROCK1 |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |