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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	non small cell lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, RIP, etc.
Sample	NSCLC tissues, NCI-H1581 [H1581] and NCI-H1993 [H1993] human NSCLC cell lines
Expression Pattern	down-regulated
Function Description	levels of HAND2-AS1 were lower in tumor tissues than that in adjacent healthy tissues. Compared with healthy controls, plasma levels of HAND2-AS1 were lower, while levels of TGF-?1 were higher in NSCLC patients. A significant negative correlation between plasma levels of HAND2-AS1 and TGF-?1 was found in NSCLC patients but not in healthy controls. LncRNA HAND2-AS1 overexpression inhibits, while exogenous TGF-?1 treatment promotes cell migration and invasion ability and cancer cell stemness. Cancer cells with lncRNA HAND2-AS1 overexpression showed downregulated TGF-?1, while TGF-?1 treatment showed no significant effects on lncRNA HAND2-AS1 expression. TGF-?1 attenuated the inhibitory effects of lncRNA HAND2-AS1 overexpression on cell migration, invasion and stemness.
Pubmed ID	30509963
Year	2018
Title	LncRNA HAND2-AS1 inhibits non-small cell lung cancer migration, invasion and maintain cell stemness through the interactions with TGF-?1

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