Basic Information
| LncRNA/CircRNA Name | AK027294 |
| Synonyms | WISP1, CCN4, WISP1c, WISP1i, WISP1tc |
| Region | GRCh38_8:133191039-133231690 |
| Ensemble | ENSG00000104415 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | CRC tissues, cell lines (HCT116, HCT8, SW480 etc.) |
| Expression Pattern | down-regulated |
| Function Description | our results indicated that AK027294 down-regulation significantly inhibited colorectal cancer cells proliferation and migration, but promoted cell apoptosis. The potential mechanism of AK027294 might be associated with the regulation of caspase-3, caspase-8, Bcl-2, MMP12, MMP9, and TWIST. The lncRNA expression profile in colorectal cancer suggests lncRNAs may play important roles in the occurrence and progression of colorectal cancer. AK027294 is highly expressed in colorectal cancer and closely correlates with colorectal cells proliferation, migration, and apoptosis |
| Pubmed ID | 26820130 |
| Year | 2016 |
| Title | Long non-coding RNA AK027294 involves in the process of proliferation, migration, and apoptosis of colorectal cancer cells |
External Links
| Links for AK027294 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |