Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | HAND2-AS1, DEIN, NBLA00301, UPH |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR, Western blot, in vitro knockdown, RNAi etc. |
| Sample | cell lines (MG-63, SAOS-2, U-2OS, HOS, SW1353) |
| Expression Pattern | up-regulated |
| Function Description | Mechanistic investigations indicated that knockdown of HAND2-AS1 abrogated the energy stress-induced effect on cell apoptosis and proliferation, and promoted osteosarcoma progression. Moreover, knockdown of HAND2-AS1 promoted glucose uptake, lactate production, and the expression level of a serious of enzymes that involved in energy metabolism.HAND2-AS1 regulated osteosarcoma metabolism through sequestering FBP1 from binding to HIF1a, thereby releasing HIF1a expression and promoting the protein level. T |
| Pubmed ID | 29637006 |
| Year | 2017 |
| Title | Energy stress-induced lncRNA HAND2-AS1 represses HIF1a-mediated energy metabolism and inhibits osteosarcoma progression. |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |