Basic Information
| LncRNA/CircRNA Name | HANR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PC, Luciferase reporter assay, other |
| Sample | HCC tissues and cell line(HepG2) |
| Expression Pattern | up-regulated |
| Function Description | esides, HANR knockdown induces attenuated cell proliferation, migration, invasion of HCC cells. By bioinformatic analysis and dual luciferase reporter assay, we found that miR-214 was the downstream target of HANR. Furthermore, miR-214 inhibitor largely enhanced tumor phenotypes of HCC cells regulated by HANR knockdown. HANR and miR-214 regulated the EZH2, then affecting TGFBR2 level. Finally, we demonstrated that EZH2 overexpression could greatly rescue HANR knockdown or miR-214 mimic-induced HCC tumorigenesis and progression. |
| Pubmed ID | 30342849 |
| Year | 2018 |
| Title | HANR Promotes Hepatocellular Carcinoma Progression via miR-214/EZH2/TGF-? Axis |
External Links
| Links for HANR | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |