Basic Information
| LncRNA/CircRNA Name | HCG18 |
| Synonyms | NA |
| Region | GRCh38_6:30287397-30327150 |
| Ensemble | ENSG00000231074 |
| Refseq | NR_024052 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | GC tissues,cell line (GES-1, MKN45, MGC803, AGS) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA-HCG18 was overexpressed in GC tissues and cells. Up-regulation of lncRNA-HCG18 was positively correlated with the stage of tumor node metastasis and invasion depth. Silencing of lncRNA-HCG18 suppressed the proliferation, migration and invasion, and induced the apoptosis of GC cells. Silencing of lncRNA-HCG18 blocked the PI3K/Akt pathway. |
| Pubmed ID | 32256081 |
| Year | 2020 |
| Title | Silencing of Long Non-Coding RNA-HCG18 Inhibits the Tumorigenesis of Gastric Cancer Through Blocking PI3K/Akt Pathway |
External Links
| Links for HCG18 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |