Basic Information
| LncRNA/CircRNA Name | HCG18 |
| Synonyms | NA |
| Region | GRCh38_6:30287397-30327150 |
| Ensemble | ENSG00000231074 |
| Refseq | NR_024052 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | RT-PCR, Western blot, Luciferase Reporter Assays |
| Sample | NPC tissues,NPC cells (C666-1, CNE-1, HONE-1, SUNE-1, HNE-1, and CNE-2) and nasopharyngeal epithelial cells (NP69) |
| Expression Pattern | up-regulated |
| Function Description | HCG18 expression was upregulated in both NPC specimens and cell lines. Higher levels of HCG18 were associated with positive lymph node metastasis and poor prognosis of NPC patients. Importantly, the multivariate analysis confirmed that HCG18 was an independent risk factor for outcome. Functionally, the downregulation of HCG18 exhibited tumor-suppressive effects via the inhibition of cell proliferation and metastasis. Mechanistically, HCG18 may directly bind to miR-140 and effectively act as a ceRNA for miR-140 to increase the expression of cyclin D1 (CCND1). In addition, HCG18 may contribute to NPC progression via modulating Wnt/?-catenin signaling and Hedgehog pathway. |
| Pubmed ID | 31841193 |
| Year | 2019 |
| Title | LncRNA HCG18 Contributes to Nasopharyngeal Carcinoma Development by Modulating miR-140/CCND1 and Hedgehog Signaling Pathway |
External Links
| Links for HCG18 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |