Basic Information
| LncRNA/CircRNA Name | HCP5 |
| Synonyms | NA |
| Region | GRCh38_6:31400702-31477506 |
| Ensemble | ENSG00000206337 |
| Refseq | NR_040662 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Luciferase reporter assay, RIP etc |
| Sample | ccRCC tissues, cell lines (786-O, Caki-2, ACHN, A498,769P, OS-RC-2,HK-2) |
| Expression Pattern | down-regulated |
| Function Description | The expression of HCP5 was significantly upregulated in ccRCC tissues and cells. Moreover, patients with high HCP5 expression level had unfavorable overall survival (OS) and progression-free survival (PFS) compared to those with low HCP5 expression. Additionally, HCP5 knockdown led to the prohibition of ccRCC cell proliferation, colony formation, migration, and invasion; the promotion of cell cycle arrest at G0-G1 and apoptosis in vitro; and the inhibition of tumor growth in vivo. Mechanically, miR-140-5p was certified as an inhibitory target of HCP5. Furthermore, insulin-like growth factor-1 receptor (IGF1R) was identified as a direct target of miR-140-5p in ccRCC cells. Finally, we found that the inhibitory effects of the HCP5 silencing on functional behaviours were neutralized by miR-140-5p silencing. |
| Pubmed ID | 32271414 |
| Year | 2020 |
| Title | Long Non-Coding RNA HCP5 Promotes Proliferation and Metastasis of Clear Cell Renal Cell Carcinoma via Targeting miR-140-5p/IGF1R Pathway |
External Links
| Links for HCP5 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |